What Are the Symptoms of Nerve Pain and Nerve Damage?
It rarely affects people younger than this. Good food sources of BCAAs and taurine include red meat, dairy, chicken, fish and eggs. Vitamins C and E A combination of the antioxidant vitamins C and E help alleviate pain after nerve injury, according to an animal study published in the December issue of "PLoS One. There are various conditions that may lead to the deficiency of this vitamin. Nerves grow very slowly and if the distance is too great they may not regenerate. Traumatic contusion injuries to nerves or nerve compressions can cause Neuropraxia. The brain and spinal cord communicates with what is occurring in the internal organs and limbs by nerve fibers where are like electrical wires with insulation myelin and the "copper" axon.
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These nerves control your movements and actions by passing information from your brain and spinal cord to your muscles. These nerves relay information from your skin and muscles back to your spinal cord and brain. The information is then processed to let you feel pain and other sensations. Autonomic nerve damage may produce the following symptoms: Inability to sense chest pain , such as angina or heart attack Too much sweating known as hyperhidrosis or too little sweating known as anhidrosis Lightheadedness Dry eyes and mouth Constipation Bladder dysfunction Sexual dysfunction Damage to motor nerves may produce the following symptoms: Weakness Muscle atrophy Twitching , also known as fasciculation Paralysis Sensory nerve damage may produce the following symptoms: Pain Sensitivity Numbness Tingling or prickling Burning Problems with positional awareness In some instances, people with nerve damage will have symptoms that indicate damage to two, or even three, different types of nerves.
Continued While not an exhaustive list, the following are some of the possible causes of nerve pain and nerve damage: A variety of different types of autoimmune diseases can produce symptoms of nerve pain and nerve damage. Cancer can cause nerve pain and nerve damage in multiple ways. In some instances, cancerous masses may push against or crush nerves. In other cases, certain types of cancer may result in nutritional deficiencies that affect nerve function.
Additionally, some types of chemotherapy and radiation may produce nerve pain and nerve damage in certain individuals. Anything that results in trauma or compression of nerves can result in nerve pain and nerve damage. This includes pinched nerves in the neck, crush injuries, and carpal tunnel syndrome. Diabetic neuropathy is a serious complication and may affect all three types of neurons. Sensory nerves are most often affected, causing burning or numbness.
If you have diabetes and are experiencing symptoms of nerve pain or nerve damage, you should consult a medical professional as soon as possible. Drug side effects and toxic substances. Various substances that are taken into the body intentionally or unintentionally have the ability to cause nerve pain and nerve damage. These include medications , such as some chemotherapies for cancer and certain drugs used to treat HIV.
Toxic substances that may be ingested accidentally, including lead, arsenic, and mercury, may also cause damage to your nerves. The motor neurons are nerves in your brain and spinal column that communicate with the muscles throughout your body. Diseases that affect these nerves, including amyotrophic lateral sclerosis , also called ALS or Lou Gehrig's disease, can result in progressively worsening nerve damage. Deficiencies of certain nutrients , including vitamins B6 and B12, may produce symptoms of nerve pain and nerve damage, including weakness or burning sensations.
Among these, the neurotransmitters serotonin, dopamine, acetylcholine, and nor-epinephrine are essential for the maintenance of the cognitive functions of the brain, and myelin is required for neuronal protection and communication as described above.
Vitamin B12 is a vital participant of the cycle because it acts as a cofactor in a very important step of the One-carbon pathway: The reasons for this step being so crucial are:.
Other B-complex vitamins like folate, vitamin B6, and vitamin B2 are also essential for the One-carbon pathway. Vitamin B12 acts as a coenzyme in another important reaction that is needed for myelin synthesis and stabilization.
Another biochemical reaction, the conversion of methylmelonyl-CoA into succinyl CoA, also requires the coenzyme cobalamin.
If this reaction does not occur, methylmalonyl-CoA gets converted to methylmalonic acid MMA , which is a myelin destabilizer. Excess MMA leads to the synthesis of abnormal fatty acids instead of myelin. These abnormal fatty acids are incorporated into neuronal lipids leading to the formation of a fragile myelin sheath. Subsequently, abnormal myelination or demyelination occurs.
The result is severe central and peripheral nervous system dysfunction. Vitamin B12 deficiency causes various neuropsychiatric problems ranging from neuropathy to dementia in the elderly. Vitamin B12 deficiency is found to cause neurological and psychiatric problems in adults between 40—90 years of age. It rarely affects people younger than this.
The neurological manifestations include myelopathy disease of the spinal cord , neuropathy disease of the nerves , sensory disturbances, gait abnormalities, and weakness, while the psychiatric problems range from cognitive and behavioral disturbances to dementia. This is a progressive degenerative condition affecting the spinal cord that is caused by vitamin B12 deficiency.
The degeneration may also involve the brain, the nerves of the eyes, and the peripheral nerves. Initially, the myelin sheath is damaged, followed by the degeneration of the axons nerves. The initial symptoms of this condition are usually a tingling sensation and numbness felt on both sides, as well as clumsy movements.
Other symptoms include weakness, visual problems, cognitive disturbances, abnormal reflexes, and bladder and erectile dysfunctions. Early treatment of this condition with vitamin B12 supplementation gives good results. A delay in treatment can result in an incomplete recovery of lost functions.
Peripheral neuropathy is also a usual presentation of vitamin B12 deficiency. In this condition, the transmission of nerve signals between the spinal cord and different parts of the body is disrupted. The problem may be due to direct damage caused to the nerves or demyelination that leads to axonal damage.
The symptoms are tingling sensations, pain, and numbness. Depending on the type of nerve affected, there can be a loss of sensation or muscle mass and activity. This condition also needs early treatment to limit damage and obtain effective results. The psychiatric manifestations of vitamin B12 deficiency include delusions, hallucinations, cognitive changes like memory decline , depression, and dementia. These problems are described by various mechanisms like the deranged production of neurotransmitters and elevated levels of homocysteine and methylmalonic acid MMA.
When there is no other obvious cause of psychiatric disorder, screening for and supplementation with vitamin B12 need to be considered.
Vitamin B12 deficiency and the resulting increase in homocysteine levels can lead to brain atrophy shrinkage. Brain atrophy usually occurs with normal aging. But this process is accelerated in the presence of neurodegenerative diseases. But a causal relationship between vitamin B12 deficiency and these diseases remains inconclusive. This means that elevated levels of homocysteine in the blood increase the risk of these diseases. Controversy also exists in the reporting of studies that evaluate an association between vitamin B12 deficiency and multiple sclerosis.
Increased levels of homocysteine in the blood is also a recognized risk factor for stroke and other vascular complications.
Thus there is a possible relationship between vitamin B12 deficiency and vascular diseases. Vitamin B12 and folate deficiencies in fetal and early life cause poor brain development and cognitive functions. Folate and vitamin B12 play very important roles in brain development, especially during the fetal and first 2 years of life. Furthermore, these vitamins are essential till puberty as myelination that starts during fetal life continues untill puberty.
As mentioned above, vitamin B12 deficiency results in restricted myelination, and depending on the area of the nervous system affected, the child can present with varied cognitive and intellectual problems.